[Pineal hormone melatonin in low doses potentiates psychotropic and chronotropic activity of tofisopam in rats]

Eksp Klin Farmakol. 2013;76(4):15-7.
[Article in Russian]

Abstract

Combination with a low dose of pineal hormone melatonin increased the anxiolytic effect of tofisopam (subthreshold dose) in open-field and cross-maze tests, as well as its chronotropic activity in time-course of forced swimming test in rats.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antidepressive Agents* / agonists
  • Antidepressive Agents* / pharmacology
  • Benzodiazepines* / agonists
  • Benzodiazepines* / pharmacology
  • Central Nervous System Depressants* / agonists
  • Central Nervous System Depressants* / pharmacology
  • Drug Agonism
  • Male
  • Maze Learning / drug effects*
  • Melatonin* / agonists
  • Melatonin* / pharmacology
  • Pineal Gland / metabolism
  • Rats

Substances

  • Antidepressive Agents
  • Central Nervous System Depressants
  • Benzodiazepines
  • Melatonin
  • tofisopam