Topical nicotinamide for seborrheic dermatitis: an open randomized study

J Dermatolog Treat. 2014 Jun;25(3):241-5. doi: 10.3109/09546634.2013.814754. Epub 2013 Jul 5.


Background: Treatment of seborrheic dermatitis (SD) includes various options with different success and safety limitations.

Objective: To evaluate the efficacy of topical nicotinamide (NCT) in the treatment of SD.

Methods: A total of 48 patients with mild to moderate SD of the face were enrolled in the study (36 males and 12 females; age 20-50 years). Patients were randomized into two groups A and B, who were treated once a day with topical administration of NCT 4% cream and with the vehicle without NCT (placebo), respectively. Clinical measures were assessed by erythema, scaling, and infiltration, which were evaluated using a four-point scale 0-3 before starting treatment and after 2, 6, and 12 weeks' therapy.

Results: In comparison with baseline, a reduction of 75% of the total score was observed in patients treated with NCT, whereas for placebo-treated patients the reduction was of 35% (p < 0.05).

Conclusion: Topical NCT 4% can have a potential for the treatment of SD.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Dermatitis, Seborrheic / drug therapy*
  • Dermatologic Agents / administration & dosage*
  • Face
  • Female
  • Humans
  • Male
  • Middle Aged
  • Niacinamide / administration & dosage*
  • Skin Cream / administration & dosage
  • Young Adult


  • Dermatologic Agents
  • Niacinamide