Tissue-resident mesenchymal stem/progenitor cells in skeletal muscle: collaborators or saboteurs?

FEBS J. 2013 Sep;280(17):4100-8. doi: 10.1111/febs.12370. Epub 2013 Jun 24.


Although the regenerative potential of adult skeletal muscle is maintained by satellite cells, other stem/progenitor cell populations also reside in skeletal muscle. These heterogeneous cellular pools with mesenchymal lineage potentially play important roles in tissue homeostasis, with reciprocal collaborations between these cells and satellite cells appearing critical for effective regeneration. However, in disease settings, these mesenchymal stem/progenitors adopt a more sinister role - likely providing a major source of fibrosis, fatty tissue and extracellular matrix protein deposition in dystrophic tissue. Development of therapies for muscle degeneration therefore requires complete understanding of the multiple cell types involved and their complex interactions.

Keywords: fibro/adipogentic progenitors; mesenchymal stem cells; muscular dystrophy; myogenesis; regenerative medicine; satellite cells; skeletal muscle; stem cells; tissue regeneration.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Humans
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / physiology
  • Muscle Development / physiology*
  • Regeneration / physiology*
  • Satellite Cells, Skeletal Muscle / cytology*
  • Satellite Cells, Skeletal Muscle / physiology