My brain told me to do it

Dev Cell. 2013 Jun 10;25(5):436-8. doi: 10.1016/j.devcel.2013.05.019.


Voluntary motor control requires circuits in the brain to develop synchronously with spinal motor circuitry. In this issue of Developmental Cell,Reimer et al. (2013) demonstrate that this process is coordinated in zebrafish: dopamine released from descending projections modulates formation of motor neurons by attenuating the response of progenitors to Shh signaling.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brain / embryology*
  • Brain / metabolism*
  • Dopamine / metabolism*
  • Gene Expression Regulation, Developmental*
  • Motor Neurons / cytology*
  • Regeneration*


  • Dopamine