Mind the IQGAP

Cancer Cell. 2013 Jun 10;23(6):715-7. doi: 10.1016/j.ccr.2013.05.017.


The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • MAP Kinase Signaling System*
  • Neoplasms / metabolism*
  • ras GTPase-Activating Proteins / metabolism*
  • ras Proteins / metabolism*


  • ras GTPase-Activating Proteins
  • ras Proteins