Significant Association Between Nijmegen Breakage Syndrome 1 657del5 Polymorphism and Breast Cancer Risk

Tumour Biol. 2013 Oct;34(5):2753-7. doi: 10.1007/s13277-013-0830-z. Epub 2013 Jun 14.

Abstract

Many studies were published to evaluate the association between Nijmegen breakage syndrome 1 (NBS1) 657del5 polymorphism and breast cancer risk, but the results remained inconsistent. To derive a more precise estimation on the possible association, we performed a meta-analysis of previous published studies. Case-control studies on the association between NBS1 657del5 polymorphisms and breast cancer risk were included into this meta-analysis. We used the odds ratio (OR) with 95 % confidence interval (95 % CI) to assess the strength of the association. Ten studies with a total of 25,365 subjects were identified and included into this meta-analysis. Meta-analysis of those ten studies showed that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk (pooled OR = 2.66, 95 % CI 1.82-3.90, P < 0.001). The cumulative meta-analyses showed a trend of a more significant association between NBS1 657del5 polymorphisms and breast cancer risk as data accumulated by publication year. Thus, our meta-analysis suggests that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk, and NBS1 657del5 polymorphism results in an increased risk of breast cancer.

Publication types

  • Meta-Analysis

MeSH terms

  • Breast Neoplasms / genetics*
  • Case-Control Studies
  • Cell Cycle Proteins / genetics*
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Nuclear Proteins / genetics*
  • Polymorphism, Genetic
  • Risk Factors
  • Sequence Deletion

Substances

  • Cell Cycle Proteins
  • NBN protein, human
  • Nuclear Proteins