[Effect of 3-oxypyridine and succinic acid derivatives on endometrial leucocyte infiltration and lipid peroxidation in recrudescence of inflammatory diseases of the uterus and its appendages]

Eksp Klin Farmakol. 2013;76(3):13-8.
[Article in Russian]

Abstract

The effect of domestic 3-oxypyridine and succinic acid derivatives (emoxipin, reamberin and mexidol) included in the complex treatment of recrudescence of inflammatory diseases of the uterus and its appendages, as manifested in endometrial leucocyte infiltration (ELI) compared to lipid peroxidation products concentration in blood serum, was assessed in a short-term, prospective placebo-controlled single-blind randomized trial. It has been found that two-week infusions of emoxipin (single dose, 150 mg), reamberin (single dose, 400 ml), and mexidol (single dose, 300 mg) favor a decrease in ELI and influence ambiguously on lipid peroxidation - antioxidant (LPA) system condition in blood serum of patients. It has been found that 3-oxypyridine derivative (emoxipin) decreases the intensity of ELI, but does not affect LPA system condition. Succinic acid derivative (reamberin) is inferior to emoxipin in the degree of decreasing ELI, but reduces the concentration of the antioxidant protein ceruloplasmin. Mexidol, being 3-oxipyridine and succinic acid derivative simultaneously, exceeds reamberin in decreasing ELI, increases concentration of blood antioxidant components (alpha-tocopherol and ceruloplasmin), and decreases the level of primary isopropanol-soluble products of lipid peroxidation.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Antioxidants / administration & dosage*
  • Ceruloplasmin / metabolism
  • Endometrium / metabolism*
  • Endometrium / pathology
  • Female
  • Humans
  • Inflammation / blood
  • Inflammation / drug therapy
  • Inflammation / pathology
  • Lipid Peroxidation / drug effects*
  • Meglumine / administration & dosage
  • Meglumine / analogs & derivatives*
  • Middle Aged
  • Picolines / administration & dosage*
  • Prospective Studies
  • Pyridines / administration & dosage
  • Single-Blind Method
  • Succinates / administration & dosage*
  • Ureteral Diseases / blood
  • Ureteral Diseases / drug therapy*
  • Ureteral Diseases / pathology
  • alpha-Tocopherol / blood

Substances

  • 3-oxypyridine
  • Antioxidants
  • Picolines
  • Pyridines
  • Reamberin
  • Succinates
  • emoxypine succinate
  • Meglumine
  • Ceruloplasmin
  • alpha-Tocopherol
  • 6-methyl-2-ethyl-3-hydroxypyridine