Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities

Food Chem. 2013 Nov 1;141(1):148-52. doi: 10.1016/j.foodchem.2013.03.039. Epub 2013 Mar 21.


Lactoferrin (Lf), the main iron-binding protein of milk, has biological activities. We have evaluated the potential of camel milk lactoferrin for its ability to inhibit the proliferation of the colon cancer cell line, HCT-116, in vitro, DNA damage and its antioxidant activities for the first time. The antioxidant capacity of Lf was evaluated by different assays, including ferric-reducing/antioxidant power assay (FRAP), free radical-scavenging activity (DPPH), nitric oxide (NO) radical-scavenging assay, total antioxidant activity and DNA damage, compared with vitamin C and rutin.

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Camelus*
  • Cell Proliferation / drug effects*
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / physiopathology*
  • DNA Damage / drug effects*
  • Down-Regulation / drug effects
  • HCT116 Cells
  • Humans
  • Lactoferrin / chemistry
  • Lactoferrin / pharmacology*
  • Milk / chemistry*


  • Antioxidants
  • Lactoferrin