Staphylococcus aureus osteomyelitis: bad to the bone

Cell Host Microbe. 2013 Jun 12;13(6):629-31. doi: 10.1016/j.chom.2013.05.015.


Osteomyelitis is a debilitating bone infection often caused by the bacterial pathogen Staphylococcus aureus. In this issue, Cassat et al. (2013) develop a high-resolution microcomputed tomography (microCT) method to visualize bone remodeling during S. aureus infection and discover that the metalloprotease aureolysin plays a critical role in modulating osteomyelitis pathogenesis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bacterial Proteins / metabolism*
  • Bone Remodeling*
  • Metalloendopeptidases / metabolism*
  • Osteomyelitis / pathology*
  • Staphylococcal Infections / pathology*
  • Staphylococcus aureus / pathogenicity*
  • Virulence Factors / metabolism*


  • Bacterial Proteins
  • Virulence Factors
  • Metalloendopeptidases
  • aureolysin