Evaluation of TNF superfamily molecules in multiple myeloma patients: correlation with biological and clinical features

Leuk Res. 2013 Sep;37(9):1089-93. doi: 10.1016/j.leukres.2013.05.014. Epub 2013 Jun 12.


B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL) and apoptosis inducing ligand (TRAIL) are members of the tumour necrosis factor (TNF) family. They are the main survival factors for immature, naive and activated B cells. We have analysed BAFF, APRIL and TRAIL serum concentrations in 52 patients with newly diagnosed IgG multiple myeloma and 20 healthy volunteers. The values were significantly higher in the studied patients and advanced diseases, decreasing after chemotherapy, compared to the control group. It was established that BAFF as APRIL (but not TRAIL) correlated with adverse prognostic factors such as IL-6 and lactate dehydrogenase. Furthermore, higher concentrations of APRIL and BAFF (but not TRAIL) predicted a shorter progression free survival, suggesting thereby an important prognostic marker and a possible therapeutic target in myeloma.

Keywords: APRIL; BAFF; Multiple myeloma; TRAIL.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • B-Cell Activating Factor / blood*
  • Biomarkers, Tumor / blood*
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma / blood*
  • Multiple Myeloma / drug therapy
  • Multiple Myeloma / mortality*
  • Prognosis
  • Survival Rate
  • TNF-Related Apoptosis-Inducing Ligand / blood*
  • Tumor Necrosis Factor Ligand Superfamily Member 13 / blood*


  • B-Cell Activating Factor
  • Biomarkers, Tumor
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human
  • TNFSF13B protein, human
  • Tumor Necrosis Factor Ligand Superfamily Member 13