Supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial--rationale and design

J Cardiol. 2013 Jul;62(1):31-6. doi: 10.1016/j.jjcc.2013.02.011. Epub 2013 Jun 12.


Background: Although angiotensin receptor blockers (ARBs) are now one of the first-line drug classes for the management of hypertension, recommendations for the management of chronic heart failure (CHF) are limited. The supplemental benefit of angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial investigates whether an additive treatment with an ARB, olmesartan, reduces the mortality and morbidity in hypertensive patients with stable chronic heart failure.

Methods and results: The SUPPORT trial is a prospective randomized open-label blinded endpoint study. Between October 2006 and March 2010, 1147 stable CHF patients treated with evidence-based medications were successfully randomized to either olmesartan or control group. In the olmesartan group, the ARB was initiated at the dose of 5.0-10mg, and was then increased up to 40mg/day, when possible. No ARBs were allowed in the control group. Primary outcome measure in the SUPPORT trial is the composite of all-cause death, non-fatal acute myocardial infarction, non-fatal stroke and hospital admission due to worsening heart failure. The participants will be followed for at least 3 years until March 2013.

Conclusions: The SUPPORT trial will elucidate the supplemental benefits of an ARB, olmesartan, in hypertensive patients with CHF.

Keywords: Angiotensin receptor blocker; Heart failure; Hypertension; Olmesartan.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II Type 1 Receptor Blockers / administration & dosage
  • Angiotensin II Type 1 Receptor Blockers / therapeutic use*
  • Angiotensin Receptor Antagonists / therapeutic use*
  • Drug Therapy, Combination
  • Heart Failure / complications*
  • Heart Failure / drug therapy
  • Humans
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Imidazoles / administration & dosage
  • Imidazoles / therapeutic use*
  • Prospective Studies
  • Tetrazoles / administration & dosage
  • Tetrazoles / therapeutic use*
  • Treatment Outcome


  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin Receptor Antagonists
  • Imidazoles
  • Tetrazoles
  • olmesartan