The balance of protein expression and degradation: an ESCRTs point of view

Curr Opin Cell Biol. 2013 Aug;25(4):489-94. doi: 10.1016/j.ceb.2013.05.003. Epub 2013 Jun 14.

Abstract

Endosomal sorting complexes required for transport (ESCRTs) execute the biogenesis of late endosomal multivesicular bodies (MVBs). The ESCRT pathway has traditionally been viewed as a means by which transmembrane proteins are degraded in vacuoles/lysosomes. More recent studies aimed at understanding the broader functions of ESCRTs have uncovered unexpected links with pathways that control cellular metabolism. Central to this communication is TORC1, the kinase complex that controls many of the catabolic and anabolic systems. The connection between TORC1 activity and ESCRTs allows cells to quickly adapt to the stress of nutrient limitations until the longer-term autophagic pathway is activated. Increasing evidence also points to ESCRTs regulating RNA interference (RNAi) pathways that control translation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Endosomal Sorting Complexes Required for Transport / metabolism*
  • Endosomes / metabolism
  • Eukaryotic Cells / metabolism
  • Humans
  • Lysosomes / metabolism
  • Membrane Proteins / metabolism*
  • Multivesicular Bodies / metabolism
  • RNA Interference
  • Yeasts / cytology*
  • Yeasts / metabolism

Substances

  • Endosomal Sorting Complexes Required for Transport
  • Membrane Proteins