Hypohidrosis induced by topiramate in an adult patient

Epileptic Disord. 2013 Jun;15(2):203-6. doi: 10.1684/epd.2013.0568.


Hypohidrosis is an uncommon and reversible side effect of topiramate treatment, reported mainly in children. This report presents an adult patient with complex partial seizures who was treated with topiramate and developed hypohidrosis coupled with hyperthermia, related to high environmental temperature and physical exercise. Reduced sweat response was confirmed using the Neuropad test. Signs and symptoms ceased after drug discontinuation. During topiramate treatment, it is important to recognise this side effect, although the exact causal mechanism has not yet been clarified.

Keywords: adverse effect; hypohidrosis; sweat function; topiramate.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticonvulsants / adverse effects*
  • Epilepsy, Complex Partial / drug therapy*
  • Fever / etiology
  • Fructose / adverse effects
  • Fructose / analogs & derivatives*
  • Humans
  • Hypohidrosis / chemically induced*
  • Hypohidrosis / complications
  • Male
  • Topiramate


  • Anticonvulsants
  • Topiramate
  • Fructose