Innate and adaptive immunity in inflammatory bowel disease

Abstract

Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC). The exact cause of IBD remains unknown. Available evidence suggests that an abnormal immune response against the microorganisms of the intestinal flora is responsible for the disease in genetically susceptible individuals. The adaptive immune response has classically been considered to play a major role in the pathogenesis of IBD. However, recent advances in immunology and genetics have clarified that the innate immune response is equally as important in inducing gut inflammation in these patients. In particular, an altered epithelial barrier function contributes to intestinal inflammation in patients with UC, while aberrant innate immune responses, such as antimicrobial peptide production, innate microbial sensing and autophagy are particularly associated to CD pathogenesis. On the other hand, besides T helper cell type (Th)1 and Th2 immune responses, other subsets of T cells, namely Th17 and regulatory T (Treg) cells, are likely to play a role in IBD. However, given the complexity and probably the redundancy of pathways leading to IBD lesions, and the fact that Th17 cells may also have protective functions, neutralization of IL-17A failed to induce any improvement in CD. Studying the interactions between various constituents of the innate and adaptive immune systems will certainly open new horizons in the knowledge about the immunologic mechanisms implicated in gut inflammation.

Keywords: Autophagy; CD; Crohn's disease; Cytokines; DC; GWAS; IBD; IFN; IL; ILC; Innate lymphoid cell; MyD88; NF; NK; NLR; NOD; NOD-like receptor; PAMP; PRR; T cell; T helper cell type; TLR; TNF; Th; Toll-like receptor; Treg; UC; dendritic cell; genome-wide association studies; iNKT; inflammatory bowel disease; innate lymphoid cell; interferon; interleukin; invariant natural killer T; myeloid differentiation primary response gene 88; natural killer; nuclear factor; nucleotide-binding oligomerization domain; pathogen associated molecular pattern; pattern recognition receptor; regulatory T cell; tumor necrosis factor; ulcerative colitis.