Walking ability and quality of life in subjects with transfemoral amputation: a comparison of osseointegration with socket prostheses

Arch Phys Med Rehabil. 2013 Nov;94(11):2174-8. doi: 10.1016/j.apmr.2013.05.020. Epub 2013 Jun 14.


Objective: To investigate walking ability and quality of life of osseointegrated leg prostheses compared with socket prostheses.

Design: Prospective case-control study.

Setting: University medical center.

Participants: Subjects (N=22) with transfemoral amputation (1 bilateral) referred to our center because of socket-related skin and residual limb problems resulting in limited prosthesis use. Their mean age was 46.5 years (range, 23-67y) and mean time since amputation was 16.4 years (range, 2-45y). Causes of amputation were trauma (n=20) and tumor (n=2).

Intervention: Implantation of an osseointegration prosthesis (OIP).

Main outcome measures: Global score of the Questionnaire for Persons With a Transfemoral Amputation (Q-TFA), prosthesis use, 6-minute walk test (6MWT), Timed Up & Go (TUG) test, and oxygen consumption during treadmill walking.

Results: With the socket prosthesis, the mean ± SD Q-TFA global score, prosthesis use, 6MWT, TUG, and oxygen consumption were 39±4.7 points, 56±7.9h/wk, 321±28m, 15.1±2.1 seconds, and 1330±310mL/min, respectively, and significantly improved with OIP to 63±5.3 points, 101±2.4h/wk, 423±21m, 8.1±0.7 seconds, and 1093±361mL/min, respectively.

Conclusions: Osseointegration is a suitable intervention for persons whose prosthesis use is reduced because of socket-related problems. Subjects with OIP significantly increased their walking ability and prosthesis-related quality of life.

Keywords: 6-minute walk test; 6MWT; Amputation; Function; Medical Outcomes Study 36-Item Short-Form Health Survey; OIP; OPRA; Osseointegrated Prosthesis for the Rehabilitation of Amputees; Osseointegration; PWS; Prosthesis; Q-TFA; Quality of life; Questionnaire for Persons With a Transfemoral Amputation; Rehabilitation; SF-36; TUG; Timed Up & Go; osseointegration prosthesis; preferred walking speed.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Amputation
  • Amputees / rehabilitation*
  • Artificial Limbs*
  • Case-Control Studies
  • Female
  • Femur / surgery
  • Humans
  • Male
  • Middle Aged
  • Osseointegration*
  • Oxygen Consumption
  • Prospective Studies
  • Prosthesis Design
  • Quality of Life*
  • Walking*
  • Young Adult