Copper catalyzed oxidative coupling of amines with formamides: a new approach for the synthesis of unsymmetrical urea derivatives

G Sathish Kumar; R Arun Kumar; P Santhosh Kumar; N Veera Reddy; K Vijaya Kumar; M Lakshmi Kantam; S Prabhakar; K Rajender Reddy

doi:10.1039/c3cc42381f

Copper catalyzed oxidative coupling of amines with formamides: a new approach for the synthesis of unsymmetrical urea derivatives

Chem Commun (Camb). 2013 Jul 28;49(59):6686-8. doi: 10.1039/c3cc42381f.

Authors

G Sathish Kumar¹, R Arun Kumar, P Santhosh Kumar, N Veera Reddy, K Vijaya Kumar, M Lakshmi Kantam, S Prabhakar, K Rajender Reddy

Affiliation

¹ Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology (CSIR-IICT), Tarnaka, Hyderabad-500 607, India.

PMID: 23774908
DOI: 10.1039/c3cc42381f

Abstract

Direct access to unsymmetrical urea derivatives via copper catalysed C-H/N-H coupling of formamides with amines has been developed at room temperature. This protocol is also applied to the synthesis of chiral urea derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry*
Catalysis
Copper / chemistry*
Formamides / chemistry*
Molecular Structure
Oxidation-Reduction
Urea / analogs & derivatives
Urea / chemical synthesis*
Urea / chemistry

Substances

Amines
Formamides
Copper
Urea