Combination of i-motif and G-quadruplex structures within the same strand: formation and application

Abstract

Peaceful coexistence: A double quadruplex composed of an i-motif and a G-quadruplex was constructed within one oligonucleotide strand (see picture). The defined double-quadruplex structure can serve as a NOTIF logic gate on the basis of the fluorescence of crystal violet.

Keywords: G-quadruplexes; circular dichroism; fluorescence; i-motifs; logic gates.