How much do we know about drug handling by SLC and ABC drug transporters in children?

Clin Pharmacol Ther. 2013 Jul;94(1):27-9. doi: 10.1038/clpt.2013.82.


Although solute carrier (SLC) and ATP-binding cassette (ABC) transporters are critical to the absorption, distribution, and elimination of many small-molecule drugs in children, how these transporters regulate pediatric drug handling remains unclear. For proper dosing and to diminish toxicity, we need a better understanding of how organ development and functional maturation, as well as developmental changes in systemic physiology, impact transporter-mediated drug handling at pediatric developmental stages from the preterm infant through adolescence.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • ATP-Binding Cassette Transporters / physiology*
  • Adolescent
  • Age Factors
  • Animals
  • Biological Transport
  • Carrier Proteins
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Membrane Transport Proteins / physiology*
  • Models, Animal
  • Rats


  • ATP-Binding Cassette Transporters
  • Carrier Proteins
  • Membrane Transport Proteins