Functions of cofilin in cell locomotion and invasion

Nat Rev Mol Cell Biol. 2013 Jul;14(7):405-15. doi: 10.1038/nrm3609. Epub 2013 Jun 19.


Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Actin Depolymerizing Factors / chemistry
  • Actin Depolymerizing Factors / physiology*
  • Actins / metabolism
  • Animals
  • Cell Movement*
  • Cell Surface Extensions / metabolism
  • Humans
  • Models, Molecular
  • Phosphorylation
  • Protein Multimerization
  • Protein Processing, Post-Translational
  • Protein Structure, Tertiary
  • Protein Transport


  • Actin Depolymerizing Factors
  • Actins