Clinical experience of integrative cancer immunotherapy with GcMAF

Anticancer Res. 2013 Jul;33(7):2917-9.


Background: Immunotherapy has become an attractive new strategy in the treatment of cancer. The laboratory and clinical study of cancer immunotherapy is rapidly advancing. However, in the clinical setting, the results of cancer immunotherapy are mixed. We therefore contend that cancer immunotherapy should be customized to each patient individually based on their immune status and propose an integrative immunotherapy approach with second-generation group-specific component macrophage activating factor (GcMAF)-containing human serum.

Patients and methods: The standard protocol of our integrative cancer immunotherapy is as follows: i) 0.5 ml GcMAF-containing human serum is administered intramuscularly or subcutaneously once or twice per week for the duration of cancer therapy until all cancer cells are eradicated; ii) hyper T/natural killer (NK) cell therapy is given once per week for six weeks; iii) high-dose vitamin C is administered intravenously twice per week; iv) alpha lipoic acid (600 mg) is administered orally daily; v) vitamin D3 (5,000-10,000 IU) is administered orally daily.

Results: By March 2013, Saisei Mirai have treated over 345 patients with GcMAF. Among them we here present the cases of three patients for whom our integrative immunotherapy was remarkably effective.

Conclusion: The results of our integrative immunotherapy seem hopeful. We also plan to conduct a comparative clinical study.>

Keywords: GcMAF; Immunotherapy; alpha lipoic acid; high-dose vitamin C; hyper T/NK cells.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Ascorbic Acid / administration & dosage
  • Bone Neoplasms / immunology
  • Bone Neoplasms / secondary
  • Bone Neoplasms / therapy*
  • Cell- and Tissue-Based Therapy
  • Combined Modality Therapy
  • Female
  • Humans
  • Immunotherapy*
  • Injections, Intramuscular
  • Injections, Subcutaneous
  • Liver Neoplasms / immunology
  • Liver Neoplasms / pathology
  • Liver Neoplasms / therapy*
  • Lung Neoplasms / immunology
  • Lung Neoplasms / secondary
  • Lung Neoplasms / therapy*
  • Macrophage-Activating Factors / administration & dosage*
  • Male
  • Prognosis
  • Prostatic Neoplasms / immunology
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy*
  • Thioctic Acid / administration & dosage
  • Thymus Neoplasms / immunology
  • Thymus Neoplasms / pathology
  • Thymus Neoplasms / therapy*
  • Vitamin D-Binding Protein / administration & dosage*


  • Macrophage-Activating Factors
  • Vitamin D-Binding Protein
  • vitamin D-binding protein-macrophage activating factor
  • Thioctic Acid
  • Ascorbic Acid