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Telomere Length and Body Temperature-Independent Determinants of Mammalian Longevity?


Telomere Length and Body Temperature-Independent Determinants of Mammalian Longevity?

Gilad Lehmann et al. Front Genet.


Figure 1
Figure 1
(A) The lnMLS residuals of lnBM and mtDNA GC correlate with telomere length (Tel). (B) The lnMLS residuals of lnBM, mtDNA GC, and Tel correlate with Tb. (C) Observed lnMLS plotted against predicted lnMLS. The predicted lnMLS was calculated from the multivariate linear regression: lnMLS = 0.14lnBM + 0.015mtDNA GC − 0.017Tel − 0.17 Tb, where MLS is in years, BM in g, mtDNA GC content in b/kb, Tel in bp, and Tb in °C. Statistical calculations were performed using the statistical package for the social sciences (SPSS, Inc., Chicago, IL) software.
Figure 2
Figure 2
Determinants of mammalian longevity. In the examined set of species, the relative contribution to MLS determination decreases in a descending order: Body mass > mtDNA GC content > Body temperature > Telomere length. Of note, 3 of 4 determinants (upper panel) are directly associated with mitochondria. For explanations, see the text.

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