The histaminergic network in the brain: basic organization and role in disease

Nat Rev Neurosci. 2013 Jul;14(7):472-87. doi: 10.1038/nrn3526.


Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important role in the maintenance of wakefulness, and dysfunction in the histaminergic system has been linked to narcolepsy. Recent evidence suggests that aberrant histamine signalling in the brain may also be a key factor in Gilles de la Tourette syndrome, Parkinson's disease and addictive behaviours. Furthermore, multiple sclerosis (MS) and experimental autoimmune encephalitis, which is an often-used model for MS, are associated with changes in the histaminergic system. This Review explores the possible roles of brain histamine in the mechanisms underlying these diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Histamine / metabolism*
  • Humans
  • Nervous System Diseases / metabolism
  • Nervous System Diseases / pathology*
  • Neural Pathways / physiology*
  • Neurotransmitter Agents / metabolism
  • Wakefulness / physiology


  • Neurotransmitter Agents
  • Histamine