A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype

Am J Hum Genet. 1990 Aug;47(2):247-54.

Abstract

The robust or model-free method for detecting linkage developed by Haseman and Elston for data from sib pairs is extended to incorporate observations of multiple traits on each individual. A method is proposed that estimates the linear function that results in the strongest correlation between the squared pair differences in the trait measurements and identity by descent at a marker locus. The method is illustrated by the study of apolipoprotein and cholesterol levels in individuals from a large family that had many members diagnosed with coronary heart disease.

MeSH terms

  • Apolipoproteins / blood
  • Apolipoproteins / genetics
  • Cholesterol, HDL / blood
  • Cholesterol, HDL / genetics
  • Cholesterol, LDL / blood
  • Cholesterol, LDL / genetics
  • Coronary Disease / blood
  • Coronary Disease / genetics*
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Lipoproteins / blood
  • Lipoproteins / genetics*
  • Models, Genetic*
  • Multivariate Analysis
  • Pedigree
  • Phenotype
  • Risk Factors

Substances

  • Apolipoproteins
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Genetic Markers
  • Lipoproteins