A robustness screen for the rapid assessment of chemical reactions

Nat Chem. 2013 Jul;5(7):597-601. doi: 10.1038/nchem.1669. Epub 2013 Jun 9.


In contrast to the rapidity with which scientific information is published, the application of new knowledge often remains slow, and we believe this to be particularly true of newly developed synthetic organic chemistry methodology. Consequently, methods to assess and identify robust chemical reactions are desirable, and would directly facilitate the application of newly reported synthetic methodology to complex synthetic problems. Here, we describe a simple process for assessing the likely scope and limitations of a chemical reaction beyond the idealized reaction conditions initially reported. Using simple methods and common analytical techniques we demonstrate a rapid assessment of an established chemical reaction, and also propose a simplified analysis that may be reported alongside new synthetic methodology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry, Organic*

Associated data

  • PubChem-Substance/162264189
  • PubChem-Substance/162264190
  • PubChem-Substance/162264191
  • PubChem-Substance/162264192
  • PubChem-Substance/162264193
  • PubChem-Substance/162264194
  • PubChem-Substance/162264195
  • PubChem-Substance/162264196
  • PubChem-Substance/162264197