Inter- and intrasubject variability of gastric emptying in healthy volunteers measured by scintigraphy and paracetamol absorption

Br J Clin Pharmacol. 1990 Jun;29(6):703-8. doi: 10.1111/j.1365-2125.1990.tb03691.x.


1. Inter- and intrasubject variability in the gastric emptying of semisolids and liquids was measured by scintigraphic emptying of radionuclide-labelled semisolid and from paracetamol absorption in ten healthy volunteers of both sexes. 2. The intrasubject variability was not statistically significant for any of scintigraphic or paracetamol absorption parameters. 3. The intersubject variation was significant for all scintigraphic and paracetamol absorption parameters. 4. In women, the gastric emptying rate of semisolid decreased linearly during the menstrual cycle. 5. The lag period and paracetamol absorption parameters were unrelated to the day of the menstrual cycle day. 6. There was no statistically significant relationship between scintigraphic and paracetamol absorption parameters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaminophen / pharmacokinetics*
  • Adult
  • Female
  • Gastric Emptying / physiology*
  • Humans
  • Intestinal Absorption
  • Male
  • Menstrual Cycle
  • Radionuclide Imaging
  • Reference Values


  • Acetaminophen