Abstract
It was shown, that in castrated rats dianabol (10 mg/kg of body mass daily for 7 days) inhibits the protein synthesis in thymus. The binding analysis of 3H-dianabol showed the specific binding sites in thymic cytosol, which are identical to those for androgens. Isolated thymocytes didn't bind dianabol.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Androgens / metabolism
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Animals
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Binding Sites
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Castration
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Cytosol / metabolism
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Male
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Methandrostenolone / administration & dosage
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Methandrostenolone / pharmacology*
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Protein Biosynthesis
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Rats
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T-Lymphocytes / metabolism
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Thymus Gland / drug effects*
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Thymus Gland / metabolism
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Time Factors
Substances
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Androgens
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Methandrostenolone