Abstract
Achiral [3.2.1] bridged heterocycles containing a bridging amide can undergo enantioselective hydroarylation reactions under rhodium(I) catalysis. These reactions proceed in high yield and enantioselectivity in most cases, under mild reaction conditions and using commercially available Josiphos ligands. The phosphine ligand structure and the protecting group on the nitrogen both have significant effects on the selectivity and yield of the reactions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Catalysis
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Heterocyclic Compounds, Bridged-Ring / chemical synthesis*
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Heterocyclic Compounds, Bridged-Ring / chemistry*
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Molecular Structure
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Rhodium / chemistry
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Stereoisomerism
Substances
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Amides
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Bridged Bicyclo Compounds, Heterocyclic
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Heterocyclic Compounds, Bridged-Ring
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homoepibatidine
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Rhodium