Ins and outs of kinase DFG motifs

Chem Biol. 2013 Jun 20;20(6):745-6. doi: 10.1016/j.chembiol.2013.06.001.


In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known "gatekeeper" residue, regulate "in" versus "out" conformations of the conserved "DFG" motif. These findings suggest yet another role for the gatekeeper residue.

Publication types

  • Comment

MeSH terms

  • Mitogen-Activated Protein Kinases / metabolism*


  • Mitogen-Activated Protein Kinases