The effect of tranexamic acid on transfusion rate in primary total hip arthroplasty

J Arthroplasty. 2014 Feb;29(2):387-9. doi: 10.1016/j.arth.2013.05.026. Epub 2013 Jun 21.


Total hip arthroplasty (THA) may produce blood loss requiring allogenic blood transfusion. Recently several authors have reported success decreasing their transfusion rate with tranexamic acid (TXA). We retrospectively reviewed our last 1595 primary THA in 1494 patients looking at whether the patients received TXA via IV infusion, topical application, or neither, and the need for a blood transfusion. Infusion of TXA acid produced a statistically significant difference in transfusion rate (p<0.001) while topical TXA failed to reach statistical significance (P=0.15). The transfusion rate without TXA was 19.86%, 4.39% with TXA infusion (odds ratio=5.36), and 12.86% (odds ratio=1.67) with topical TXA.

Keywords: antifibrinolytics; blood loss; total hip arthroplasty; tranexamic acid; transfusion rate.

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Aged, 80 and over
  • Antifibrinolytic Agents / administration & dosage
  • Antifibrinolytic Agents / adverse effects*
  • Arthroplasty, Replacement, Hip / adverse effects*
  • Blood Loss, Surgical / prevention & control*
  • Blood Transfusion*
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Postoperative Hemorrhage / etiology
  • Postoperative Hemorrhage / prevention & control*
  • Retrospective Studies
  • Tranexamic Acid / administration & dosage
  • Tranexamic Acid / adverse effects*
  • Treatment Outcome
  • Young Adult


  • Antifibrinolytic Agents
  • Tranexamic Acid