Neuronal circuits that regulate feeding behavior and metabolism

Trends Neurosci. 2013 Sep;36(9):504-12. doi: 10.1016/j.tins.2013.05.003. Epub 2013 Jun 19.


Neurons within the central nervous system receive humoral and central (neurotransmitter or neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent advances in mouse genetics combined with neuroanatomical and electrophysiological techniques have contributed to a better understanding of these central mechanisms. This review integrates recently defined cellular mechanisms and neural circuits relevant to the regulation of feeding behavior, energy expenditure, and glucose homeostasis by metabolic signals.

Keywords: GABA; agouti-related peptide; electrophysiology; glutamate; melanocortin receptor; neuropeptide Y receptor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Central Nervous System / cytology*
  • Central Nervous System / metabolism*
  • Energy Metabolism / physiology*
  • Feeding Behavior / physiology*
  • Humans
  • Neurons / physiology*
  • Neuropeptides / metabolism
  • Neurotransmitter Agents / metabolism


  • Neuropeptides
  • Neurotransmitter Agents