New roles of cyclin D1

Am J Pathol. 2013 Jul;183(1):3-9. doi: 10.1016/j.ajpath.2013.03.001.


Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis has been well characterized, new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of mitochondrial metabolism, regulation of transcription factor signaling via a DNA-bound form, the induction of chromosomal instability, enhancement of DNA damage sensing and DNA damage repair, and feedback governing expression of the noncoding genome. This review describes the mechanisms of these new functions of cyclin D1.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Chromosomal Instability / physiology
  • Cyclin D1 / physiology*
  • DNA Repair / physiology
  • Gene Expression Regulation
  • Humans
  • Mice
  • Mitochondria / metabolism


  • Cyclin D1