Guarding against collateral damage during chromatin transactions

Cell. 2013 Jun 20;153(7):1431-4. doi: 10.1016/j.cell.2013.05.044.

Abstract

Signal amplifications are vital for chromatin function, yet they also bear the risk of transforming into unrestrained, self-escalating, and potentially harmful responses. Examples of inbuilt limitations are emerging, revealing how chromatin transactions are confined within physiological boundaries.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena
  • Chromatin / metabolism*
  • DNA Damage
  • DNA Repair*
  • Gene Expression Regulation
  • Humans
  • M Phase Cell Cycle Checkpoints
  • Signal Transduction
  • Transcription, Genetic*

Substances

  • Chromatin