Metabolic Signaling in Fuel-Induced Insulin Secretion

Cell Metab. 2013 Aug 6;18(2):162-85. doi: 10.1016/j.cmet.2013.05.018. Epub 2013 Jun 20.

Abstract

The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin according to the needs of the organism. Altered insulin secretion is linked to various disorders such as diabetes, hypoglycemic states, and cardiometabolic diseases. Fuel stimuli, including glucose, free fatty acids, and amino acids, promote insulin granule exocytosis primarily via their metabolism in β cells and the production of key signaling metabolites. This paper reviews our current knowledge of the pathways involved in both positive and negative metabolic signaling for insulin secretion and assesses the role of established and candidate metabolic coupling factors, keeping recent developments in focus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / blood
  • Amino Acids / metabolism
  • Blood Glucose / metabolism
  • Diabetes Mellitus / metabolism*
  • Energy Metabolism / physiology*
  • Fatty Acids, Nonesterified / blood
  • Fatty Acids, Nonesterified / metabolism
  • Glucose / metabolism
  • Humans
  • Insulin / metabolism*
  • Insulin Secretion
  • Insulin-Secreting Cells / metabolism*
  • Signal Transduction / physiology*

Substances

  • Amino Acids
  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Insulin
  • Glucose