The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson's disease

Parkinsonism Relat Disord. 2013 Oct;19(10):889-93. doi: 10.1016/j.parkreldis.2013.05.017. Epub 2013 Jun 19.


Objective: To evaluate the motor experiences of daily living section of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS M-EDL) for assessing disability in PD patients; to determine the association between disability and quality of life; and to identify cut-off score ranges for no, mild, moderate and severe disability with this measure.

Methods: International, observational, cross-sectional study of 435 PD patients, assessed with: MDS-UPDRS, Hoehn and Yahr staging, Rapid Assessment of Disability Scale, Clinical Impression of Severity Index for PD, Parkinson's Disease Questionnaire-8 and EQ-5D. Descriptive statistics, Spearman's rank correlation coefficients, Kruskal-Wallis test for group comparisons, ordinal logistic regression analysis for setting cut-off values and a step-wise multiple linear regression model were calculated.

Results: MDS-UPDRS M-EDL correlated 0.70-0.80 with other disability measures, and -0.46 to 0.74 with quality of life scales. Scores significantly increased with higher disease duration and severity (p < 0.001). Cut-off values for the M-EDL were: 0-2 points, no disability; 3-16, mild; 17-31, moderate; and 32 points or more, severe. Linear regression analysis identified the MDS-UPDRS nM-EDL section as the main determinant of M-EDL, followed by the rest of MDS-UPDRS sections (explained variance: 59%).

Conclusions: MDS-UPDRS M-EDL proved to be useful for assessing disability in PD.

Keywords: Assessment; Disability; MDS-UPDRS; Parkinson's disease; Rating scales.

Publication types

  • Meta-Analysis
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living*
  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Disability Evaluation*
  • Disease Progression
  • Female
  • Health Status
  • Humans
  • Linear Models
  • Logistic Models
  • Male
  • Middle Aged
  • Movement / physiology*
  • Parkinson Disease / diagnosis
  • Parkinson Disease / physiopathology*
  • Predictive Value of Tests
  • Psychomotor Performance / physiology
  • Quality of Life
  • Reproducibility of Results
  • Socioeconomic Factors
  • Surveys and Questionnaires