Testing long-term memory in animal models of schizophrenia: suggestions from CNTRICS

Timothy J Bussey; Deanna M Barch; Mark G Baxter

doi:10.1016/j.neubiorev.2013.06.005

Testing long-term memory in animal models of schizophrenia: suggestions from CNTRICS

Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2141-8. doi: 10.1016/j.neubiorev.2013.06.005. Epub 2013 Jun 18.

Authors

Timothy J Bussey¹, Deanna M Barch, Mark G Baxter

Affiliation

¹ Department of Experimental Psychology and The MRC and Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, CB2 3EB, UK. Electronic address: tjb1000@cam.ac.uk.

PMID: 23792049
DOI: 10.1016/j.neubiorev.2013.06.005

Abstract

This paper reports the results of discussions at the fourth meeting of Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) meeting, held over two days in Washington, DC in April 2011. The meeting focused on animal paradigms for assessing the cognitive constructs relevant to schizophrenia identified in previous CNTRICS meetings. This report focuses on the outcome of discussions in the general area of long-term memory. A number of candidate animal paradigms were discussed. Two of these - one for rodents and one for non-human primates - were recommended as particularly promising for further development.

Keywords: Episodic memory; Hippocampus; Mouse; Neuropsychiatric disease; Object recognition; Paired-associate learning; Prefrontal cortex; Rat; Relational memory; Rodent; Touchscreen.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal
Humans
Memory Disorders / diagnosis*
Memory Disorders / etiology*
Memory, Long-Term / physiology*
Schizophrenia / complications*

Grant support

G0001354/Medical Research Council/United Kingdom