Feasibility of using C-reactive protein for point-of-care testing

Technol Health Care. 2013;21(3):233-40. doi: 10.3233/THC-130720.


Background: C-reactive protein (CRP) point-of-care testing (POCT) can be a valuable tool for decision making in primary care. Very few studies have illustrated the utilization of CRP POCT.

Objective: To conduct a systematic review on the use of CRP POCT in primary care settings and to examine its feasibility and acceptability in an outpatient primary care setting.

Methods: The search was conducted via PubMed. Final articles in the systematic review met inclusion and exclusion criteria. For the feasibility and acceptability analysis, a convenience sample of 20 adult subjects was enrolled and CRP POCT was conducted.

Results: Antibiotic prescription was the most predominant outcome assessed, and antibiotic prescription reduction was the most common finding of CRP POCT effectiveness testing.

Conclusion: CRP POCT can be used to detect inflammation and can reduce antibiotic prescription in primary care. It is a satisfactory procedure that should be available in the primary care setting.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Biomarkers / blood
  • C-Reactive Protein / metabolism*
  • Child
  • Feasibility Studies
  • Female
  • Humans
  • Inappropriate Prescribing / prevention & control
  • Inflammation / diagnosis*
  • Male
  • Nebraska
  • Point-of-Care Systems*
  • Primary Health Care
  • Respiratory Tract Infections / drug therapy


  • Anti-Bacterial Agents
  • Biomarkers
  • C-Reactive Protein