Bromodomain proteins in HIV infection

Viruses. 2013 Jun 21;5(6):1571-86. doi: 10.3390/v5061571.


Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Gene Expression Regulation, Viral*
  • HIV / physiology*
  • Host-Pathogen Interactions*
  • Humans
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / metabolism*
  • Protein Binding
  • Protein Conformation
  • Protein Interaction Domains and Motifs
  • Viral Proteins / metabolism*
  • Virus Integration*
  • Virus Replication*


  • Nuclear Proteins
  • Viral Proteins