The regulation and function of microRNAs in kidney diseases

IUBMB Life. 2013 Jul;65(7):602-14. doi: 10.1002/iub.1174.

Abstract

MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have been implicated in renal development, homeostasis, and physiological functions. In addition, miRNAs play important roles in the pathogenesis of various renal diseases, including renal carcinoma, diabetic nephropathy, acute kidney injury, hypertensive nephropathy, polycystic kidney disease, and others. Furthermore, miRNAs may have great values as biomarkers in different kidney diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Acute Kidney Injury / genetics
  • Acute Kidney Injury / pathology
  • Biomarkers*
  • Homeostasis
  • Humans
  • Kidney Diseases / classification
  • Kidney Diseases / genetics*
  • Kidney Diseases / pathology*
  • MicroRNAs / genetics*

Substances

  • Biomarkers
  • MicroRNAs