Reduced postmovement cortical inhibition in patients with paroxysmal kinesigenic dyskinesia

Neurology. 2013 Jul 23;81(4):353-60. doi: 10.1212/WNL.0b013e31829c5e61. Epub 2013 Jun 21.

Abstract

Objective: To characterize movement-related neural oscillatory activity and to clarify its neurophysiologic role in paroxysmal kinesigenic dyskinesia (PKD).

Methods: We recorded neuromagnetic event-related desynchronization (ERD) and event-related synchronization (ERS) activities in response to a self-paced finger-lifting task in 16 patients with PKD and 17 healthy controls.

Results: The amplitude of α-ERD was comparable between the healthy controls and patients with PKD, whereas either the contralateral or ipsilateral β-ERS was decreased. The peak latency of contralateral β-ERS was delayed in patients with PKD. Patients with less frequent dyskinetic attacks demonstrated a larger ipsilateral β-ERS. Moreover, some patients with PKD revealed a lesser degree of contralateral preponderance of β-ERS generation.

Conclusions: The present data imply a decreased postmovement inhibition of motor cortex in patients with PKD, and the inhibitory function in the contralateral hemisphere is more affected than that in the ipsilateral hemisphere.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain Mapping
  • Chorea / physiopathology*
  • Cortical Synchronization / physiology*
  • Dystonia
  • Electromyography
  • Evoked Potentials, Motor / physiology*
  • Female
  • Functional Laterality
  • Humans
  • Magnetoencephalography
  • Male
  • Middle Aged
  • Motor Cortex / physiopathology*
  • Neural Inhibition / physiology*
  • Psychomotor Performance / physiology
  • Reaction Time / physiology
  • Young Adult

Supplementary concepts

  • Familial paroxysmal dystonia