Diadenosine tetraphosphate (Ap4A) levels in HL-60 cells during differentiation into granulocytes and monocytes

Int J Biochem. 1990;22(6):665-8. doi: 10.1016/0020-711x(90)90046-6.

Abstract

1. Diadenosine tetraphosphate (Ap4A) levels were determined in HL-60 cells differentiating into granulocytes or monocytes after treatment for 0-7 days with retinoic acid (RA) or 4-beta-phorbol-12-myristate-13-acetate (PMA) respectively. 2. The levels increased significantly compared to untreated control cells within 2 days and then declined again. 3. In RA treated cells the levels finally decreased far below those of untreated HL-60 cells and became equal to those found in human granulocytes. 4. PMA treatment had no effect on Ap4A levels in human granulocytes. 5. A possible interaction between Ap4A and ADP-ribosyl transferase is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Differentiation
  • Dinucleoside Phosphates / metabolism*
  • Granulocytes / cytology*
  • Granulocytes / drug effects
  • Granulocytes / metabolism
  • Humans
  • Leukemia, Promyelocytic, Acute / metabolism*
  • Leukemia, Promyelocytic, Acute / pathology
  • Monocytes / cytology*
  • Tetradecanoylphorbol Acetate / pharmacology
  • Tretinoin / pharmacology
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / metabolism

Substances

  • Dinucleoside Phosphates
  • diadenosine tetraphosphate
  • Tretinoin
  • Tetradecanoylphorbol Acetate