Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 13 (7), 475-86

How B Cells Capture, Process and Present Antigens: A Crucial Role for Cell Polarity

Affiliations
Review

How B Cells Capture, Process and Present Antigens: A Crucial Role for Cell Polarity

Maria-Isabel Yuseff et al. Nat Rev Immunol.

Abstract

B cells are key components of the adaptive immune response. Their differentiation into either specific memory B cells or antibody-secreting plasma cells is a consequence of activation steps that involve the processing and presentation of antigens. The engagement of B cell receptors by surface-tethered antigens leads to the formation of an immunological synapse that coordinates cell signalling events and that promotes antigen uptake for presentation on MHC class II molecules. In this Review, we discuss membrane trafficking and the associated molecular mechanisms that are involved in antigen extraction and processing at the B cell synapse, and we highlight how B cells use cell polarity to coordinate the complex events that ultimately lead to efficient humoral responses.

Similar articles

See all similar articles

Cited by 75 articles

See all "Cited by" articles

References

    1. J Immunol. 2008 May 15;180(10):6685-95 - PubMed
    1. Cell Signal. 2004 Jan;16(1):1-11 - PubMed
    1. Blood. 2008 Jun 15;111(12 ):5621-8 - PubMed
    1. Annu Rev Immunol. 1994;12:117-39 - PubMed
    1. Annu Rev Immunol. 1997;15:453-79 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback