The spectrum of MOG autoantibody-associated demyelinating diseases

Nat Rev Neurol. 2013 Aug;9(8):455-61. doi: 10.1038/nrneurol.2013.118. Epub 2013 Jun 25.


Myelin oligodendrocyte glycoprotein (MOG) has been identified as a target of demyelinating autoantibodies in animal models of inflammatory demyelinating diseases of the CNS, such as multiple sclerosis (MS). Numerous studies have aimed to establish a role for MOG antibodies in patients with MS, although the results have been controversial. Cell-based immunoassays using MOG expressed in mammalian cells have demonstrated the presence of high-titre MOG antibodies in paediatric patients with acute disseminated encephalomyelitis, MS, aquaporin-4-seronegative neuromyelitis optica, or isolated optic neuritis or transverse myelitis, but only rarely in adults with these disorders. These studies indicate that MOG antibodies could be associated with a broad spectrum of acquired human CNS demyelinating diseases. This Review article discusses the current literature on MOG antibodies, their potential clinical relevance, and their role in the pathogenesis of MOG antibody-associated demyelinating disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoantibodies / blood
  • Demyelinating Autoimmune Diseases, CNS / immunology*
  • Humans
  • Myelin-Oligodendrocyte Glycoprotein / immunology*


  • Autoantibodies
  • Myelin-Oligodendrocyte Glycoprotein