Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. Sep-Oct 2012;1(5):753-72.
doi: 10.1002/wdev.43. Epub 2012 Apr 4.

Primary Cilia and Graded Sonic Hedgehog Signaling

Affiliations
Review

Primary Cilia and Graded Sonic Hedgehog Signaling

Noriaki Sasai et al. Wiley Interdiscip Rev Dev Biol. .

Abstract

Cilia are evolutionary-conserved microtubule-containing organelles protruding from the surface of cells. They are classified into two types--primary and motile cilia. Primary cilia are nearly ubiquitous, at least in vertebrate cells, and it has become apparent that they play an essential role in the intracellular transduction of a range of stimuli. Most notable among these is Sonic Hedgehog. In this article we briefly summarize the structure and biogenesis of primary cilia. We discuss the evidence implicating cilia in the transduction of extrinsic signals. We focus on the involvement and molecular mechanism of cilia in signaling by Sonic Hedgehog in embryonic tissues, specifically the neural tube, and we discuss how cilia play an active role in the interpretation of gradients of Sonic Hedgehog (Shh) signaling.

Similar articles

See all similar articles

Cited by 35 articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback