Circulating CLA+ T lymphocytes as peripheral cell biomarkers in T-cell-mediated skin diseases

Exp Dermatol. 2013 Jul;22(7):439-42. doi: 10.1111/exd.12154.


T lymphocytes expressing the CLA antigen constitute a subset of effector memory lymphocytes that are functionally involved in T-cell-mediated cutaneous diseases. Skin-seeking lymphocytes recirculate between inflamed skin and blood during cutaneous inflammation. Many studies in different T-cell-mediated inflammatory cutaneous diseases have clearly related their pathologic mechanisms to CLA+ T cells. Based on common features of these cells in different cutaneous disorders mediated by T cells, we propose that circulating CLA+T cells could constitute very useful peripheral cellular biomarkers for T-cell-mediated skin diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation, T-Lymphocyte / metabolism
  • Biomarkers / metabolism*
  • Humans
  • Immunologic Memory
  • Inflammation
  • Membrane Glycoproteins / metabolism
  • Mice
  • Phenotype
  • Psoriasis / immunology
  • Skin Diseases / immunology*
  • Skin Neoplasms / immunology
  • T-Lymphocytes / cytology*


  • Antigens, Differentiation, T-Lymphocyte
  • Biomarkers
  • CTAGE1 protein, human
  • Membrane Glycoproteins