Turning acne on/off via mTORC1

Exp Dermatol. 2013 Jul;22(7):505-6. doi: 10.1111/exd.12180.

Abstract

Over the past 10 years, the increase in comprehension of the mechanisms behind acne has been truly exponential. Starting with the ethnological work of Cordain, accelerated by the epidemiological work of Adebamowo, supported by the clinical trials of Smith and Mann, Kwon, DiLandro and others, the interface of diet and acne is coming into focus. Melnik now presents an exceptional pair of papers that illustrate for dermatologists what translational research is all about. The Western diet, the role of dairy, FoxO1 and mTORC1, the interplay of agonists and antagonists, therapeutics present and future - the jigsaw puzzle is coming together.

MeSH terms

  • Acne Vulgaris / metabolism*
  • Acne Vulgaris / therapy*
  • Animals
  • Child
  • Clinical Trials as Topic
  • Diet
  • Humans
  • Insulin / metabolism
  • Mechanistic Target of Rapamycin Complex 1
  • Milk
  • Multiprotein Complexes / metabolism*
  • Protein Binding
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • Insulin
  • Multiprotein Complexes
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1