Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology

J Hematol Oncol. 2013 Jun 24:6:42. doi: 10.1186/1756-8722-6-42.


With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Platelets / metabolism*
  • Humans
  • Neoplasms / blood*
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Neovascularization, Pathologic
  • Peptides / blood*
  • Platelet Factor 4 / blood*


  • Peptides
  • Platelet Factor 4
  • connective tissue-activating peptide