Ailing bones and failing kidneys: a case of chronic cadmium toxicity

Ann Clin Biochem. 2013 Sep;50(Pt 5):492-5. doi: 10.1177/0004563213481207. Epub 2013 Jun 25.

Abstract

Heavy metal toxicity is often caused by occupational exposure. Chronic cadmium toxicity is a significant health concern among workers engaged in zinc smelting, battery production and silver jewellery industries, particularly in developing countries. We report the case of a 48-year-old man who presented with severe osteoporosis, impaired renal function and acquired Fanconi syndrome. He was finally diagnosed with chronic cadmium toxicity resulting from long-term occupational exposure. Cadmium has a long biological half-life and there is no effective treatment for people who are exposed to it. Therefore, an early diagnosis and prevention of further exposure are important.

Keywords: Disease; bone disorders; toxicology.

Publication types

  • Case Reports

MeSH terms

  • Bone and Bones / metabolism
  • Bone and Bones / pathology
  • Cadmium / blood
  • Cadmium / urine
  • Cadmium Poisoning / blood
  • Cadmium Poisoning / diagnosis*
  • Cadmium Poisoning / urine
  • Fanconi Syndrome / blood
  • Fanconi Syndrome / chemically induced
  • Fanconi Syndrome / diagnosis*
  • Fanconi Syndrome / urine
  • Humans
  • Kidney / metabolism
  • Kidney / pathology
  • Male
  • Middle Aged
  • Occupational Exposure / adverse effects*
  • Osteoporosis / blood
  • Osteoporosis / chemically induced
  • Osteoporosis / diagnosis*
  • Osteoporosis / urine
  • Renal Insufficiency, Chronic / blood
  • Renal Insufficiency, Chronic / chemically induced
  • Renal Insufficiency, Chronic / diagnosis*
  • Renal Insufficiency, Chronic / urine

Substances

  • Cadmium