MIF: metastasis/MDSC-inducing factor?

Oncoimmunology. 2013 Mar 1;2(3):e23337. doi: 10.4161/onci.23337.


Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor. Our results suggest that MIF is a potential therapeutic target for the prevention of metastasis as it regulates the tumor microenvironment.

Keywords: MDSC; MIF; metastasis; sulforaphane; tautomerase; tumor microenvironment.