Lack of association between factor V Leiden and sepsis: a meta-analysis

Clin Appl Thromb Hemost. 2015 Apr;21(3):204-10. doi: 10.1177/1076029613494470. Epub 2013 Jun 25.


Some studies evaluated the association of factor V Leiden (FVL) with sepsis risk and mortality risk. However, the results were conflicting. Thus, we performed a meta-analysis to address the association between FVL and sepsis. PubMed and EMBASE databases were searched to find relevant studies. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random effects model. Five case-control studies and 3 cohort studies were included. Overall, no significant association between FVL and sepsis risk was observed (OR = 0.93; 95% CI 0.74-1.15; P = .49). In addition, there was no significant association between FVL and sepsis-related mortality (OR = 1.17; 95% CI 0.73-1.88; P = .52). In the subgroup analysis, no increased sepsis risk and mortality risk were found in caucasian population. This meta-analysis suggested that FVL was not a risk factor for sepsis and sepsis mortality.

Keywords: factor V Leiden; meta-analysis; sepsis.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Case-Control Studies
  • Factor V / genetics*
  • Female
  • Humans
  • Male
  • PubMed
  • Risk Factors
  • Sepsis / genetics*
  • Sepsis / mortality*


  • factor V Leiden
  • Factor V