Relationship between red cell distribution width and stroke in patients with stable chronic heart failure: a propensity score matching analysis

Clin Appl Thromb Hemost. 2015 Mar;21(2):160-5. doi: 10.1177/1076029613493658. Epub 2013 Jun 25.


Aim: We aimed to investigate the association between baseline red cell distribution width (RDW) level and the risk of stroke in patients with heart failure (HF).

Methods: A total of 153 consecutive patients with HF (New York Heart Association [NYHA] I-III and left ventricular ejection fraction of <40%) were included in this prospective study. All the patients were followed up for 1 year, and during this period the cerebrovascular disease was questioned.

Results: In matched population, using propensity score matching comparing patients with HF having stroke with patients without stroke, we found significantly increased basal RDW and serum uric acid. The receiver-operating characteristic curves of RDW for predicting stroke are performed. An RDW ≥ 15.2% measured on admission had 87% sensitivity and 74% specificity in predicting stroke in patients with HF (area under the curve: 0.923, 95% confidence interval: 0.852-0.994, P < .001).

Conclusion: In conclusion, this study demonstrated that RDW may be important hematological indices for stroke in patients with HF using propensity score analysis.

Keywords: heart failure; red cell distribution width; stroke.

MeSH terms

  • Aged
  • Chronic Disease
  • Erythrocyte Indices*
  • Female
  • Heart Failure / blood*
  • Heart Failure / complications
  • Heart Failure / epidemiology*
  • Heart Failure / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Propensity Score
  • Risk Factors
  • Stroke / blood*
  • Stroke / embryology*
  • Stroke / etiology
  • Stroke / physiopathology
  • Stroke Volume